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| BUPROPION HYDROCHLORIDE | ||
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PRODUCT IDENTIFICATION |
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CAS NO. |
31677-93-7 |
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| EINECS NO. | ||
| FORMULA | C13H18ClNO·HCl | |
| MOL WT. | 276.21 | |
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H.S. CODE |
2934.90 | |
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TOXICITY |
Oral rat LD50: 980mg/kg | |
| SYNONYMS | Wellbutrin; Zyban; | |
| (±)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride; (±)-2-(tert-Butylamino)-3'- chloropropiophenone hydrochloride; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | White crystalline powder, odourless | |
| MELTING POINT |
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| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER |
Soluble |
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| pH | ||
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| AUTOIGNITION |
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| NFPA RATINGS | ||
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REFRACTIVE INDEX |
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| FLASH POINT |
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| STABILITY |
Stable under ordinary conditions. |
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APPLICATIONS |
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| Bupropion, also called amfebutamone, is used as an antidepressant agent. But it is a monocyclic compound structurally while most antidepressant are tri or tetra cyclic compounds. It inhibits dopamine and norepinephrine transporters but does not inhibit the serotonin transporter. It is also used as a non-nicotine aid to smoking cessation to reduce the symptoms of nicotine withdrawal, though it doesn't have related chemical structure to nicotine. The hydrochloride salt of bupropion is a white crystalline powder with a bitter taste; very soluble in water, methanol and ethanol. The chemical designation is (±)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
White to off-white crystalline powder | |
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ASSAY |
98.0 - 102.0% |
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SULFATED ASH |
0.1% max |
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LOSS ON DRYING |
0.5% max |
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WATER |
0.2% max |
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TOTAL IMPURITY |
1.0% max |
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| TRANSPORTATION | ||
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| HAZARD CLASS | ||
| UN NO. | ||
| OTHER INFORMATION | ||
| Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 36 | ||
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